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ETD RECORD
Toll-like receptor agonists as monotherapies and vaccine adjuvants provide protection against potential biological weapons Yersinia pestis and Francisella tularensis
Citation
Airhart, Christina Luanne.. (2008). Toll-like receptor agonists as monotherapies and vaccine adjuvants provide protection against potential biological weapons Yersinia pestis and Francisella tularensis. Theses and Dissertations Collection, University of Idaho Library Digital Collections. https://www.lib.uidaho.edu/digital/etd/items/etd_350.html
- Title:
- Toll-like receptor agonists as monotherapies and vaccine adjuvants provide protection against potential biological weapons Yersinia pestis and Francisella tularensis
- Author:
- Airhart, Christina Luanne.
- Date:
- 2008
- Keywords:
- Biological weapons--Vaccination Yersinia pestis--Vaccination Francisella tularensis--Vaccination
- Program:
- Microbiology, Molecular Biology, and Biochemistry
- Abstract:
- 880-01Yersinia pestis and Francisella tularensis, the causative agents of plague and tularemia, have been labeled as potential biological weapons. In the event of an intentional aerosol release of either pathogen, the only FDA-approved treatment is rigorous antibiotic therapy. The focus of this research was to determine if use of known immune stimulants could provide rapid and sustained vaccine protection against pneumonic infections of Y. pestis or F. tularensis.;880-02The AGPs also functioned effectively as adjuvant in a plague vaccine. Our two-dose intranasal (i.n.) vaccine with Y. pestis -derived Caf1 and V antigens provided mice with 100% protection just 21 days after the priming dose. A single i.n. vaccine protected more than 75% of vaccinates 45-180 days post-vaccine. The protection levels seen from our AGP-based vaccine correlated well with total sera IgG titers and promoted a mixed Th1/Th2 response. Our intranasal vaccine protected 90% of Sprague-Dawley rats challenged with 1000LD{esc}b50{esc}s Y. pestis.
- Description:
- Thesis (Ph. D., Microbiology, Molecular Biology and Biochemistry)--University of Idaho, October 2008.
- Major Professor:
- Scott A. Minnich.
- Defense Date:
- October 2008.
- Type:
- Text
- Format Original:
- ix, 90 leaves :ill. ;29 cm.
- Format:
- record
Rights
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